Daily Management Review

The Antibiotic Resistant S.aureus Can Be Destroyed With The New ‘Antibody-Antibiotic Conjugate,


11/13/2015


A new conjugate between the antibody of S. aureus and an antibiotic is now capable of killing “intracellular S.aureus bacteria.



The Antibiotic Resistant S.aureus Can Be Destroyed With The New ‘Antibody-Antibiotic Conjugate,
The nature.com announces a discovery of new antibody which can ‘eliminate’ the “intracellular S.aureus”.
 
S.aureus, or otherwise known as Staphylococcus aureus is regarded as an “extracellular pathogen”. If the said bacterium finds a shelter in “host cells” then they can become “relatively protected from antibiotics” guarded by their cellulous “reservoir”.
 
S.aureus is a “gram-positive coccal bacterium” that comes from the phylum of Firmicutes. They are often located in the human “respiratory tract” and on the skin membrane where perspiration settles down.
 
Generally, the said bacterium causes “nitrate reduction”; some believe that it not “always pathogenic”. Commonly, it leads to various skin infections like “abscesses”, “respiratory infections” like “sinusitis, and food poisoning”. Moreover:
“The emergence of antibiotic-resistant forms of S. aureus such as MRSA is a worldwide problem in clinical medicine”.
 
The antibiotic resistant S. aureus enables “long-term colonization of the host” and leads to “clinical failures” which results in “relapses” after an “antibiotic therapy”.
 
Nevertheless, nature.com announces that:
“...intracellular reservoirs of S. aureus in mice comprise a virulent subset of bacteria that can establish infection even in the presence of vancomycin, and we introduce a novel therapeutic that effectively kills intracellular S. aureus”.
 
The therapy consists of an “antibody–antibiotic conjugate” wherein the antibody of an “anti-S. aureus” is “conjugated” to an antibiotic which is “highly efficacious” and gets activated once it gets “released in the proteolytic environment of the phagolysosome”.
 
Informing further about the conjugate of antidoby-antibiotic, nature.com writes:
“The antibody–antibiotic conjugate is superior to vancomycin for treatment of bacteraemia and provides direct evidence that intracellular S. aureus represents an important component of invasive infections”.





References:
www.nature.com
 







Science & Technology

Wreck Of Russian Ship Rumoured To Have 5,500 Boxes Of Gold Found Near South Korean Island

Gene Editing of Human Embryo Could Find ‘Moral’ Grounds: UK’s Ethics Council

Baidu comes up with a self-driving bus

Developing countries are stepping up their own space programs

McAfee: Number of cybercrime attacks skyrocketed

RemoveDebris Mission To Clear Debris Of In Orbit Over Earth

British experts: Online gambling is dangerous

Vodafone Chooses ‘Highly Trafficked Urban’ Space As Its 5G Testing Grounds

Space To Become A Travel Destination By 2022

Dream Of Immortality Can Be Realised By 2045

World Politics

World & Politics

Ireland pledges to stop investing in fossil fuels

Germany asks to return € 4 thousand subsidies for the purchase of Tesla

Was Trump's visit to the UK the last straw?

Prime Minister May Could Alter Brexit Strategies, Said Ress-Mogg

Le Maire: The US refused to release France from anti-Iran sanctions

One Belt, One Road is facing difficulties around the world

Qatar to raise $ 4 billion to buy Eurofighter Typhoon jets

The UK sets to turn all cars zero-emission by 2030